I still have issues understanding due to language, sorry.. not sure what you mean by "adds the folders of issabel database".
On one post there is a mention of Mariadb being run with skip grant tables.. if that is true, then that is surely a problem that might cause all kind of troubles, including unresponsive GUI, etc.
Solution would be to start the database without skip grant tables most probably.
If your box is hacked, then changing the password is usually not enough, you might have a backdor already in place, an unprivileged user that you do not know you have, a rogue .php script that exposes a remote shell with the asterisk user and without authentication, etc. Hard to tell, and it is just all a guess. It is not possible to give any sound advise without the proper assesment I mentioned.